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The Robert-Sauvé occupational safety and health research institute (IRSST) recently published the first study of the type to better understand and establish how human cells such as the eosinophil (Eo) react when they are placed in the presence of nanoparticles (NPs).
Using an experimental approach, the researchers drew up a list of 17 NPs which could have effects on the biology of Eos. The Eos had been isolated from fresh blood coming from healthy persons forming part of a donor bank. The Eos were then treated in vitro with increasing concentrations of various NPs during periods ranging from a few minutes to 24 hours in order to assess the modulatory capacity of functions all related to the inflammatory process, i.e. the capacity of NPs for affecting the production of reactive oxygen species (ROS), chemotaxis, adhesion, apoptosis and the production of certain cytokines.